Acanthosis nigricans - 黑棘皮病
這在肥胖者中很常見。
relevance score : -100.0%
ReferencesAcanthosis nigricans 是潛在疾病的皮膚表現。它常見於頸部、腋窩、腹股溝等皮膚皺褶處，呈現天鵝絨狀的黑色斑塊，邊緣不清晰。此情況通常與糖尿病及胰島素阻抗相關，但在極少數情況下，可能提示體內存在癌症。荷爾蒙失調或使用類固醇、避孕藥等特定藥物亦可導致此現象。
Acanthosis nigricans is a cutaneous manifestation of an underlying condition. It usually develops in skin folds, such as the back of the neck, axilla, and groin, where it presents as velvety hyper-pigmented patches with poorly defined borders. Acanthosis nigricans is most commonly associated with diabetes and insulin resistance, but rarely it can be a sign of internal malignancy. It can also occur with hormone disorders or with the use of certain medications like systemic glucocorticoids and oral contraceptives.
Acanthosis nigricans is a cutaneous manifestation of an underlying condition. It usually develops in skin folds, such as the back of the neck, axilla, and groin, where it presents as velvety hyper-pigmented patches with poorly defined borders. Acanthosis nigricans is most commonly associated with diabetes and insulin resistance, but rarely it can be a sign of internal malignancy. It can also occur with hormone disorders or with the use of certain medications like systemic glucocorticoids and oral contraceptives.
Acanthosis nigricans (AN) 是一種常見的皮膚病，與胰島素抗性、糖尿病、肥胖、某些癌症、荷爾蒙問題以及藥物反應等多種健康問題相關。治療 AN 的重點在於解決潛在的健康問題。首先，醫師會檢查是否存在胰島素抗性症候群的徵象，包括肥胖、高膽固醇、高血壓和第二型糖尿病。醫師常以 topical retinoids 作為第一線治療，這有助於改善皮膚增厚，但可能無法完全消除皮膚變黑的情況。其他可選的治療方式包括 salicylic acid、podophyllin、urea 以及 calcipotriol，需依患者情況持續使用。
Acanthosis nigricans (AN) is a common dermatologic manifestation of systemic disease that is associated with insulin resistance, diabetes mellitus, obesity, internal malignancy, endocrine disorders, and drug reactions. Treatment of AN primarily focuses on resolution of the underlying disease processes causing the velvety, hyperpigmented, hyperkeratotic plaques found on the skin. Initial considerations for the AN workup include evaluating patients for insulin resistance syndrome characterized by obesity, dyslipidemia, hypertension, and diabetes mellitus type II. For cosmetic treatment, topical retinoids are considered the first-line therapy for insulin-resistant AN by modifying keratinization rate. However, topical tretinoin requires application for long durations and improves hyperkeratosis, but not hyperpigmentation. Topical salicylic acid, podophyllin, urea, and calcipotriol also require frequent application, while TCA peels may provide a faster and less time-intense burden.
Acanthosis nigricans (AN) is a common dermatologic manifestation of systemic disease that is associated with insulin resistance, diabetes mellitus, obesity, internal malignancy, endocrine disorders, and drug reactions. Treatment of AN primarily focuses on resolution of the underlying disease processes causing the velvety, hyperpigmented, hyperkeratotic plaques found on the skin. Initial considerations for the AN workup include evaluating patients for insulin resistance syndrome characterized by obesity, dyslipidemia, hypertension, and diabetes mellitus type II. For cosmetic treatment, topical retinoids are considered the first-line therapy for insulin-resistant AN by modifying keratinization rate. However, topical tretinoin requires application for long durations and improves hyperkeratosis, but not hyperpigmentation. Topical salicylic acid, podophyllin, urea, and calcipotriol also require frequent application, while TCA peels may provide a faster and less time-intense burden.
○ 原因
多發於40歲以下者，可能具有遺傳傾向，且常與肥胖或內分泌疾病有關，如甲狀腺功能減退症、肢端肥大症、多囊性卵巢病、胰島素抗性糖尿病或庫欣氏症。
○ 治療 - 非處方藥
#40% urea cream